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TRPM4 抑制剂，9-邻菲罗尔-CAS 484-17-3-Calbiochem
TRPM4 inhibitor, 9-Phenanthrol-CAS 484-17-3-Calbiochem
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4170041 | 50 MG | 1220 |
产品别名
484-17-3
TRPM4 抑制剂，9-邻菲罗尔-CAS 484-17-3-Calbiochem
TRPM4 inhibitor, 9-Phenanthrol-CAS 484-17-3-Calbiochem
Phenanthren-9-ol, 9-Hydroxyphenanthrene
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H10O |
| Molecular weight | 194.23 |
| MDL number | MFCD00082298 |
| General description【一般描述】 | A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents. |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697. Simard, C., 2012. Brit. Journ. Pharm.165, 2354. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | brown |
| solubility【溶解性】 | DMSO: 50 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H |
| InChI key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
| packaging【包装】 | 50 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
