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NS8593-Calbiochem
| 产品编号： | 4168147 |
| 规格： | An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
NS8593-Calbiochem
(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H17N3 |
| Molecular weight | 263.34 |
| MDL number | MFCD32671885 |
| General description【一般描述】 | An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; Kd = 420 nM, 600 nM, and 730 nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50 = 1.6 mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Chubanov, V., et al. 2012. Brit. Journ. Pharm.166, 1357. Jenkins, D., et al. 2011. Hypertension.57, 1129. Jenkins, D., et al. 2011. Mol. Pharm.79, 899. Jenkins, D., et al. 2011. Mol. Pharm.79, 899. Lasse, S., et al. 2011. J. Cardiov. Pharm.57, 672. Diness, J., et al. 2010. Circ Arrhythm Electrophusiol.3, 380. Ji, H., et al. 2009. Eur. J. Neurosci.9, 1883. Strobaek, D., et al. 2006. Mol. Pharm.70, 1771. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 100 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | C1(NC(N[C@@H]2CCCC3=C2C=CC=C3)=N4)=C4C=CC=C1 |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
