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氨基蝶呤
Methotrexate Related Compound B
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4157945 | 75 MG | 12320 |
产品别名
54-62-6
氨基蝶呤
Methotrexate Related Compound B
4-Aminopteroyl-
4-Aminofolic acid
(S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid
4-Amino-PGA
Aminopterin
N-[4-[[(2,4-二氨基-6-蝶啶)甲基]氨基]苯甲酰]-
(S)-2- {4-[(2,4-二氨基胍-6-基)甲氨基]苯甲酰氨基}戊二酸
4-氨基-PGA
4-氨基叶酸
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H20N8O5 |
| Molecular weight | 440.41 |
| Beilstein | 69045 |
| PubChem Substance ID【PubChem化学物质编号】 | 329750411 |
| NACRES | NA.24 |
| General description【一般描述】 | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. |
| Biochem/physiol Actions【生化/生理作用】 | 叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。 |
| Linkage【联系】 | 比甲氨喋呤更有效，但毒性也更强。 |
| Analysis Note【分析说明】 | These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. |
| Other Notes【其他说明】 | USP issued SDS can be found here. Sales restrictions may apply. |
产品性质
| grade【等级】 | pharmaceutical primary standard |
| manufacturer/tradename | USP |
| ε (extinction coefficient) | 24,500 at 282 nm in 0.1 M NaOH at 1 M 25,700 at 261 nm in 0.1 M NaOH at 1 M 8,100 at 373 nm in 0.1 M NaOH at 1 M |
| application(s) | pharmaceutical (small molecule) |
| format【格式】 | neat |
| SMILES string | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |
| InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1 |
| InChI key | TVZGACDUOSZQKY-LBPRGKRZSA-N |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 - H360 |
| Precautionary Statements | P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Oral - Repr. 1B |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
