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InSolution CXCR4 Antagonist I, AMD3100-CAS 155148-31-5-Calbiochem
| 产品编号： | 4157510 |
| 规格： | InSolution |
| CAS NO： | 155148-31-5 |
| 包装规格： | 15 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4157510 | 15 MG | 2400 |
产品别名
155148-31-5
InSolution CXCR4 Antagonist I, AMD3100-CAS 155148-31-5-Calbiochem
1,1'(1,4-Phenylenebis(methylene))-bis-1,4,8,11-tetraazacyclotetradecane, 8HCl, 4H2O, 1,4-bis((1,4,8,11-Tetraazacyclotetradecan-1-yl)methyl)benzene, 8HCl, 4H2O
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H54N8 · 8HCl · 4H2O |
| Molecular weight | 866.53 |
| General description【一般描述】 | A symmetrical bicyclam compound that antagonizes CXCL12 (SDF1) binding to CXCR4 (IC50 = 108 and 245 nM using rat and human CXCR4, respectively) and inhibits SDF1-induced Ca2+ flux (by 100% at 100 ng/ml in SUP-T1 and THP-1 cultures) as well as CXCR4-, but not CCR5-, mediated HIV infection (IC50 = 200 nM), while enhancing the binding of SDF1 to CXCR7 (by ~60% at 1 mM with CXCR7-expressing HEK293T cells) and SDF1-induced β-arrestin recruitment to CXCR7 (EC50 = 6.48 and 11.8 nM, in the presence and absence of 10 µM AMD3100, respectively). Administration AMD3100 via intravenous infusion is also reported to result in hematopoietic stem cell mobilization in humans, dogs, and mice in vivo. Exhibits no inhibitory effects against chemokine-induced signaling via CXCR1/2/3 or CCR1/2/3/4/5/6/7/8/9. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target CXCR4 Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | A 50 mM (15 mg/308 µL) solution of CXCR4 Antagonist I, AMD3100 (Cat. No. 239820) in H₂O. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C. |
| Other Notes【其他说明】 | Kalatskaya, I., et al. 2009. Mol. Pharmacol.77, 1240. Pitchford, S.C., et al. 2009. Cell Stem Cell4, 62. De Clercq, E. 2009. Biochem. Pharmacol.77, 1655. Thoma, G., et al. 2008. J. Med. Chem.51, 7915. De Clercq, E. 2000. Mol. Pharmacol.57, 833. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| InChI | 1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H |
| InChI key | UEUPDYPUTTUXLJ-UHFFFAOYSA-N |
| packaging【包装】 | 15 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 3 |
