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ERO1 Inhibitor I, Erodoxin-Calbiochem
| 产品编号： | 4156761 |
| 规格： | The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1. |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
ERO1 Inhibitor I, Erodoxin-Calbiochem
1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C7H5BrN2O5 |
| Molecular weight | 277.03 |
| MDL number | MFCD00624873 |
| General description【一般描述】 | A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC50 = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C. |
| Other Notes【其他说明】 | Costanzo, M., et al. 2010. Science327, 425. Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 100 mg/mL (Use only fresh DMSO) |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O |
| packaging【包装】 | 25 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
