DNA-PK Inhibitor-CAS 20357-25-9-Calbiochem

C₉H₉NO₅

211.17

MFCD00007134

A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC₅₀ = 15 µM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC₅₀ = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities.

Cell permeable: yes
Primary Target
DNA-PK activity
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 15 µM against DNA-PK (DNA-dependent protein kinase) activity

Toxicity: Carcinogenic / Teratogenic (D)

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% (GC)

solid

Calbiochem^®

OK to freeze
protect from light

bright yellow

DMSO: 5 mg/mL

ambient

2-8℃

1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3

YWSPWKXREVSQCA-UHFFFAOYSA-N

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3