c-Raf Inhibitor-Calbiochem

C₂₃H₁₉F₃N₈O

480.45

A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC₅₀ value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI ₅₀ = 2.68 µM) and WM3629 (GI₅₀ = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC₅₀ value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI ₅₀ = 2.68 µM) and WM3629 (GI₅₀ = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Yu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze

off-white

DMSO: 10 mg/mL

ambient

2-8℃

20 mg in Glass bottle

11 - Combustible Solids

WGK 3