Bexarotene-CAS 153559-49-0-Calbiochem

C₂₄H₂₈O₂

348.48

MFCD00932428

A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.

Cell permeable: yes
Reversible: yes

Toxicity: Regulatory Review (Z)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Cramer, P.E., et al. 2012. Science Exp.335, 1503.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥99% (HPLC)

powder

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 50 mg/mL, clear, colorless

ambient

−20℃

1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)

NAVMQTYZDKMPEU-UHFFFAOYSA-N

50 mg in Glass bottle
Packaged under inert gas

11 - Combustible Solids

WGK 3