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Anti-VPAC2 Antibody
| 产品编号： | 4155073 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-VPAC2 Antibody
vasoactive intestinal peptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, vasoactive intestinal polypeptide receptor 2, PACAP type III receptor
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Vasoactive intestinal polypeptide receptor 2 (VPAC2), also known as PACAP type III receptor or PACAP-R3 for short, is a class B G-protein-coupled receptor. Three distinct PACAP receptors have been identified. Of the three, only PACAP-3 has been found expressed in Sartoli cells of the testis and is coupled to G and adenylyl cyclase, thus having a potential influence on the production of cAMP. In the immune system, PACAP-R3 is expressed on stimulated CD4 T cells, and binding of T cell-derived VIP to-PACAP-R3 induces a shift toward the Th2 pathway. In addition, PACAP-R3 is an essential regulator of the circadian pacemaker of the hypothalamic suprachiasmatic nuclei (SCN). |
| Specificity【特异性】 | This antibody recognizes VCAP2 (PACAP-R3) at the extracellular domain. Other homologies: mouse (84% sequence homology). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the extracellular domain of human VPAC2 (PACAP-R3). |
| Application【应用】 | Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected VPAC2 in normal human cerebral cortex and T cells inside the mantle zone of normal human tonsil tissues. Anti-VPAC2 Antibody is an antibody against VPAC2 for use in WB, IH(P). |
| Quality【质量】 | Evaluated by Western Blot in Jurkat cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected VPAC2 on 10 µg of Jurkat cell lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | rhesus macaque (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology), pig (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_003373 |
| UniProt accession no.【UniProt登记号】 | P41587 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~52 kDa observed. An uncharacterized band appears at ~39 kDa in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
