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Anti-pan-Shank Antibody, clone N23B/49
产品别名
Anti-pan-Shank Antibody, clone N23B/49
SH3 and multiple ankyrin repeat domains 2, SH3 and multiple ankyrin repeat domains protein 2, proline-rich synapse associated protein 1, cortactin SH3 domain-binding protein, Cortactin-binding protein 1, Proline-rich synapse-associated protein 1, cortact
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Shank1, Shank2, and Shank3 make up a family of proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank contains multiple domains for protein-protein interaction including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile α motif domain, and a proline-rich region. Alternative splicing in the Shank family may be a mechanism that regulates the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. |
| Immunogen【免疫原】 | Recombinant protein consisting of SH3/PDZ domain of rat Shank2. |
| Application【应用】 | Research Sub Category Synapse & Synaptic Biology Detect pan-Shank using this Anti-pan-Shank Antibody, clone N23B/49 validated for use in WB, IH(P). Research Category Neuroscience Immunohistochemistry Analysis: 1:500 dilution from a previous lot detected Shank in rat cerebellum tissue. Western Blot Analysis: A previous lot of this antibody detected Shank in extracts of COS-1 cells transiently transfected with Shank1, Shank2 or Shank3 plasmids. Courtesy of James Trimmer, UC Davis/NIH NeuroMab Facility. |
| Quality【质量】 | Evaluated by Western Blot in rat brain membrane tissue lysate. Western Blot Analysis: 2 µg/mL of this antibody detected Shank on 10 µg of rat brain membrane tissue lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G |
| Analysis Note【分析说明】 | Control Rat brain membrane tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | N23B/49, monoclonal |
| species reactivity | rat, mouse, human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_001004133 |
| UniProt accession no.【UniProt登记号】 | Q9QX74 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SHANK2(22941) |
产品说明
| Target description【目标描述】 | ~160 kDa observed. Other isoforms may be observed in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
