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Anti-GABA B Receptor R2 Antibody
产品别名
Anti-GABA B Receptor R2 Antibody
G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of rat GABA-B-R2. |
| Immunogen【免疫原】 | Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2. |
| Application【应用】 | Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB. |
| Quality【质量】 | Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region. Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region. |
| Linkage【联系】 | Replaces: AB5394 |
| Analysis Note【分析说明】 | Unpurified |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | guinea pig |
| antibody form【抗体形式】 | serum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | rhesus macaque, rat |
| species reactivity (predicted by homology) | rhesus monkey (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology), horse (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_113990 |
| UniProt accession no.【UniProt登记号】 | O88871 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... GABBR2(9568) |
产品说明
| Target description【目标描述】 | Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
