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Anti-Atg18 (WIPI-2) Antibody, clone 2A2
产品别名
Anti-Atg18 (WIPI-2) Antibody, clone 2A2
WD repeat domain phosphoinositide-interacting protein 2, WIPI-2, WIPI49-like protein 2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Atg18, also known as WIPI-2, is involved in autophagy by regulating the assembly of mulitprotein complexes by presenting a 7-bladed propeller structure for interactions with phospholipids. Atg18 is a mammalian effector of PtdIns3P and is ubiquitously expressed in a variety of cell lines. Studies show that Atg18 is recruited to early autophagosomal structural formation along with Atg16 and ULK1, and Atg18 is required for the formation of LC3-positive autophagosomes. |
| Specificity【特异性】 | This antibody recognizes Atg18 at the C-terminus. |
| Immunogen【免疫原】 | Linear peptide corresponding to the C-terminus of human Atg18. Epitope: C-terminus |
| Application【应用】 | Research Sub Category Apoptosis - Additional This Anti-Atg18 (WIPI-2) Antibody, clone 2A2 is validated for use in WB, IH(P) for the detection of Atg18 (WIPI-2). Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Atg18 in human colorectal adenocarcinoma tissue. Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blot in human testis tissue lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Atg18 in 10 µg of human testis tissue lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Human testis tissue lysate |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 2A2, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_001028690 |
| UniProt accession no.【UniProt登记号】 | Q9Y4P8 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... WIPI2(26100) |
产品说明
| Target description【目标描述】 | ~49 kDa observed. 6 isoforms exist with molecular weights ranging from 42 kDa to 48 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
