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产品别名
Anti-ABBA Antibody
actin-bundling protein with BAIAP2 homology
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Radial glia play key roles in neuronal migration, axon guidance, and neurogenesis during development of the central nervous system. However, the molecular mechanisms regulating growth and morphology of these extended cells are unknown. ABBA, a novel member of the IRSp53/MIM protein family, is enriched in different types of radial glia. ABBA binds ATP-actin monomers with high affinity and deforms PIP2-rich membranes in vitro through its WH2 and IMdomains, respectively. In radial glia-like C6-R cells, ABBA localizes to the interface between the actin cytoskeleton and plasma membrane, and its depletion by RNAi leads to defects in lamellipodial dynamics and process extension. Together, ABBA acts as a novel regulator of actin and plasma membrane dynamics in radial glial cells, and provides evidence that the membrane binding/deformation activity is critical for the cellular functions of IRSp53/MIM/ABBA family proteins |
| Specificity【特异性】 | Cat. # AB2209 recognizes ABBA May react with Pan troglodytes and Macaca mulatta based on sequence homology. Reactivity with other species was not tested. |
| Immunogen【免疫原】 | Recombinant protein. |
| Application【应用】 | Research Sub Category Neuronal & Glial Markers Anti-ABBA Antibody is an antibody against ABBA for use in WB, IC, IH. Research Category Neuroscience Non-Lot Specific Tested Application 1: Immunocytochemistry: 1:50 dilution in mouse primary glial cell line and C6, C6-R rat cell line. Non-Lot Specific Tested Application 2: Immunohistochemistry: 1:1,000 in embryonic and adult brain tissue. (See Reference for more information) |
| Quality【质量】 | Routinely tested on mouse brain lysate Lot Specific Tested Application 1: Western Blot |
| Physical form【外形】 | Serum with with 0.05% NaN3 |
| Analysis Note【分析说明】 | Control Mouse brain lysate |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | serum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human, mouse, rat |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_941027 |
| UniProt accession no.【UniProt登记号】 | Q6P9S0 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~82 kDa |
| Storage and Stability【储存及稳定性】 | Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
