Aminopeptidase N/CD13 Inhibitor-Calbiochem

C₁₃H₂₂NO₃P

271.29

An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC₅₀=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.
An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC₅₀=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Grzywa, R., et al. 2010. Bioorg. Med. Chem.8, 2930.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze

white

0.1 M NaOH: 1 mg/mL
DMSO: 1 mg/mL (Only partially soluble)
water: 1 mg/mL (only partially soluble)

wet ice

−20℃

10 mg in Glass bottle

11 - Combustible Solids

WGK 2