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3-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid
产品别名
3-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid
Rigid linker for PROTAC development
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H26N2O5 |
| Molecular weight | 374.43 |
| Application【应用】 | 3-(2-(tert-Butoxycarbonyl)-5-oxo-2,6-diazaspiro[3.6]decan-6-yl)benzoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex. Similar linkers in this series: 920592 920614 920622 920630 |
| Other Notes【其他说明】 | Portal: Building PROTAC® Degraders for Targeted Protein Degradation Crosslinkers for Bioconjugation Technology Spotlight:Degrader Building Blocks for Targeted Protein Degradation |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| form【形式】 | powder |
| Quality Level【质量水平】 | 100 |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=CC(C(O)=O)=C3)C1)=O)C CC(C)(OC(N1CC2(CCCCN(C2=O)C3=CC=CC(C(O)=O)=C3)C1)=O)C |
