Guanabenz Acetate-CAS 23256-50-0-Calbiochem

C₈H₈Cl₂N₄ · xC₂H₄O₂

231.08 (free base basis)

MFCD00153801

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC₅₀ ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥99% (HPLC)

powder

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

water: 5 mg/mL

ambient

2-8℃

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

MCSPBPXATWBACD-GAYQJXMFSA-N

250 mg in Glass bottle
Packaged under inert gas

GHS06

Danger

H301

P264 - P270 - P301 + P310 - P405 - P501

Acute Tox. 3 Oral

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3