您的位置：首页 > 产品中心 > FTI-276-Calbiochem
FTI-276-Calbiochem
| 产品编号： | 4144724 |
| 规格： | A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). |
| 包装规格： | 250 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
FTI-276-Calbiochem
N-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H27N3O3S2 |
| Molecular weight | 433.59 |
| General description【一般描述】 | A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM. |
| Biochem/physiol Actions【生化/生理作用】 | Target IC50: 500 pM against FTase in vitro Product does not compete with ATP. Reversible: no Primary Target FTase in vitro Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C. |
| Other Notes【其他说明】 | Lantry, L.E., et al. 2000. Carcinogenesis21, 113. Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802. Sun, J., et al. 1995. Cancer Res. 55, 4243. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥90% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 250 μg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
