MMP-2/MMP-9 Inhibitor IV-CAS 292605-14-2-Calbiochem

C₁₅H₁₄O₃S₂

306.40

MFCD09836266

A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM) and MMP-9 (K_i = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (K_i = 206 µM) MMP-3 (K_i = 15 µM), or MMP-7 (K_i = 96 µM).
A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM), and MMP-9 (K_i = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.

Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

Krüger, A., et al. 2005. Cancer Res.65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem.276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc.122, 6799.

Sold under license of U.S. Patent 6,703,415.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

13.9 nM K_i

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 100 mg/mL

ambient

−20℃

500 μg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3