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TFF1 human
| 产品编号： | 4140963 |
| 规格： | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) |
| 包装规格： | 20 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
TFF1 human
TFF-1
BCEI
HPS
TFF1
HP1
pS2
基本信息
| MDL number | MFCD07370822 |
| NACRES | NA.32 |
| General description【一般描述】 | Trefoil factor 1(TFF1) is a member of trefoil factor family (TFF) and is encoded by the gene mapped to human chromosome 21q22.3. Recombinant human TFF1 is an 8.2kDa polypeptide containing 60 amino acid residues. TFF1 consists of trefoil motif, which is a 40-amino acid domain with three conserved disulfides. TFF1 is expressed and secreted by epithelial cells in the stomach or colon mucous membrane. |
| Biochem/physiol Actions【生化/生理作用】 | Trefoil factor family (TFF) members play a vital role in mucus stabilization and stimulation of normal epithelial cell restitution during wound healing via motogenic and antiapoptotic activities. TFF1 prevents anoikis, chemicals or bad-induced apoptosis by decreasing the caspase-3, caspase-6, caspase-8, and caspase-9 activities. TFF1 functions as a tumor suppressor in gastric cancer, whereas it acts as a tumor promoter in mucinous ovarian cancer via regulating the Wnt/β-catenin signaling pathway. Elevated level of TFF1 is observed in patients suffering from Chronic kidney disease (CKD). TFF1 might function as a biomarker for early detection of CKD. |
| Physical form【外形】 | Sterile filtered and lyophilized powder. |
| Reconstitution【重悬】 | Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers. Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | ~8.2 kDa |
| packaging【包装】 | pkg of 20 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| impurities【杂质】 | endotoxin, tested |
| NCBI accession no.【NCBI登记号】 | P04155 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TFF1(7031) |
