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Sorafenib
产品性质
| Assay【测定】 | >95% (TLC) |
| form【形式】 | lyophilized powder |
| mol wt【分子量】 | ~464.8 |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
基本信息
| Application【应用】 | Clinically useful anticancer agent. |
| Biochem/physiol Actions【生化/生理作用】 | Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-beta (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM) (1). Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms (2). Inhibits activation of MAPK pathway and ERK phosphorylation (3). Induces caspase-independent apoptosis in melanoma cells (4). |
| Reconstitution【重悬】 | Formulated as a lyophilized powder. May be dissolved in DMSO (200 mg/mL) or Ethanol (3 mg/mL). |
产品说明
| Storage and Stability【储存及稳定性】 | Store desiccated as supplied at -20℃ for up to 2 years. Store solutions at -20℃ for up to 1 month. |
安全信息
| Pictograms【象形图】 | GHS08,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H360FD - H362 - H372 - H410 |
| Precautionary Statements | P202 - P260 - P263 - P264 - P273 - P308 + P313 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 1B - STOT RE 1 |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
