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PDE4B (305-end), active, GST tagged human
| 产品编号： | 4139599 |
| 规格： | recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| CAS NO： | 1653990-78-3 |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
1653990-78-3
PDE4B (305-end), active, GST tagged human
DKFZp686F2182
PDE4B5
PDEIVB
DPDE4
MGC126529
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | PDE4B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and has homology to the ′dunce′ gene of Drosophila. The ′dunce′ gene is one of several genes critical for normal learning and memory in the fly. Altered activity of PDE4B has been associated with schizophrenia and bipolar affective disorder. DISC1 interacts with the UCR2 domain of PDE4B and elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity. PDE4B gene itself does not link to major depressive disorder (MDD) but elevated mRNA levels of PDE4B have been implicated in the pathophysiology of MDD. |
| Physical form【外形】 | Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| Specific Activity | 457-619 nmol/min·mg |
| mol wt【分子量】 | ~78 kDa |
| NCBI accession no.【NCBI登记号】 | NM_002600 |
| application(s) | cell analysis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PDE4B(5142) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
