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BMP-10 human
| 产品编号： | 4116874 |
| 规格： | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) |
| 包装规格： | 20 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
BMP-10 human
BMP 10
bone morphogenetic protein 10
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-10 is essential for the proper development of the heart, but is not expressed until after cardiac patterning or looping are completed. Recombinant human BMP-10 is a 32 kDa disulfide-linked homodimer containing two 142 amino acid polypeptide chains. The bone morphogenetic protein 10 (BMP10) gene spans ~7.8 kb on human chromosome 2p13.3. It is highly expressed in the trabeculae of the embryonic heart, but it is expressed at low levels in the liver and the lungs. BMP-10 belongs to the bone morphogenetic protein (BMP) family. |
| Biochem/physiol Actions【生化/生理作用】 | Bone morphogenetic protein 10 (BMP10) acts as a potent tumor suppressor in prostate, gastric and breast cancer. It is implicated in trabeculation of the embryonic heart. BMP10 retards the growth of prostate cancer cells via, apoptosis induced by X- inhibitor of apoptosis protein (XIAP) and extracellular signal–regulated kinase (ERK)1/2 dependent signaling and SMAD-independent signaling. In addition, it also has an ability to inhibit prostate cancer cell migration and invasiveness. Elevated expression of the gene inhibits growth, adhesion and migration of bladder cancer cells in vitro. Thus, this protein can be considered as a potent therapeutic target for bladder cancer. |
| Physical form【外形】 | Sterile filtered and Lyophilized without additives. |
| Reconstitution【重悬】 | Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers Centrifuge the vial prior to opening. Avoid freeze-thaw cycles. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | ~32 kDa |
| packaging【包装】 | pkg of 20 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| impurities【杂质】 | endotoxin, tested |
| NCBI accession no.【NCBI登记号】 | O95393 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BMP10(27302) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
