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BIO 1211 trifluoroacetate salt
产品别名
187735-94-0
BIO 1211 trifluoroacetate salt
N-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-proline trifluoroacetate
N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-Leu-Asp-Val-Pro trifluoroacetate
BIO1211 trifluoroacetate
2-MPUPA-LDVP trifluoroacetate
N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-LDVP trifluoroacetate
4-(N′-(2-Methylphenyl)urea)-phenylacetyl-LDVP trifluoroacetate
N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-fibronectin CS-1 fragment (1980-1983) trifluoroacetate
BIO-1211 trifluoroacetate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C36H48N6O9 · xC2HF3O2 |
| Molecular weight | 708.80 (free base basis) |
| MDL number | MFCD02259692 |
| Biochem/physiol Actions【生化/生理作用】 | BIO 1211 is a selective, tight-binding α4β1 (VLA-4, very late antigen-4; koff = 1.4 x 10-4/s, KD = 70 pM) integrin antagonist (VCAM-Ig Jurkat surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β1, 2 μM/α4β7, >100 μM/α1β1, α5β1, α6β1, αLβ2, αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responses, BIO 1211 is also widely used in animal disease models in vivo, including MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to mice, rats, sheep; 3 mg/sheep iv.). |
产品性质
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | film lyophilized powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to beige |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
