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B7-2/CD86 human

产品编号:4116668
规格:recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
包装规格:10 μG,50 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411666810 μG3450
411666850 μG11460
产品别名

B7-2/CD86 human

B70

MGC34413

LAB72

CD28LG2

基本信息
NACRES
NA.32
General description【一般描述】
Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.
Physical form【外形】
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution【重悬】
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in HEK 293 cells
tag【标签】
6-His tagged (C-terminus)
Assay【测定】
≥95% (SDS-PAGE)
form【形式】
lyophilized
mol wt【分子量】
calculated mol wt 26.7 kDa
observed mol wt 43-60 kDa (DTT-reduced.Protein migrates due to glycosylation. Gly 24 is the predicted N-terminal.)
packaging【包装】
pkg of 10 μg
pkg of 50 μg
impurities【杂质】
<1 EU/μg endotoxin (LAL test)
UniProt accession no.【UniProt登记号】
P42081
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CD86(942)
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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