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ATAT1 人
ATAT1 human
| 产品编号： | 4116542 |
| 规格： | recombinant, expressed in E. coli, ≥55% (SDS-PAGE) |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
ATAT1 人
ATAT1 human
MEC17
TAT
alpha tubulin acetyltransferase 1
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Human α tubulin acetyltransferase 1, or ATAT1, (GenBank Accession No. NM_001031722 (var1)), amino acids 2 – 224 with N-terminal GST-tag, MW=52 kDa, expressed in an E. coli expression system. The αTAT1 (α tubulin acetyltransferase 1) protein sequence of αTAT1 is highly conserved among eukaryotes. αTAT1 is a member of Gcn5 (general control non-depressible 5)-related N-acetyltransferase superfamily and is mostly present in ciliated organisms. It has also been identified in Tetrahymena, nematodes, zebrafish and mice. |
| Biochem/physiol Actions【生化/生理作用】 | ATAT1 (α tubulin acetyltransferase 1) catalyses the acetylation of lysine 40 of α-tubulin and microtubule. ATAT1 expression is essential for microtubule stabilization and mediates cilium formation. Upart from acetylation, αTAT1 interacts with doublecortin (a microtubule associated protein) to degrade microtubules that are not aligned with acetyltransferase activity. αTAT1 regulates the Wnt1 signalling pathway via β-catenin and promotes tumorigenesis. Overexpression of the ATAT1 gene is observed in colon cancer and is known to contribute to its progression. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥55% (SDS-PAGE) |
| form【形式】 | aqueous solution |
| mol wt【分子量】 | 52 kDa |
| packaging【包装】 | pkg of 50 μg |
| NCBI accession no.【NCBI登记号】 | NM_001031722 (var1) |
| UniProt accession no.【UniProt登记号】 | Q5SQI0 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... ATAT1(79969) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
