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Anti-S1P lyase Antibody
| 产品编号： | 4114648 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-S1P lyase Antibody
S1PL, SPL1, mSPL, Sphingosine-1-phosphate aldolase
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | S1P lyase is an important enzyme in lipid, steroid, and ceramide metabolism. S1P lyase 1 specifically cleaves phosphorylated sphingoid bases such as sphingosine-1-phosphate into fatty aldehydes and phosphoethanolamine. S1P lyase also plays roles in apoptosis with regards to regulation of ceramide production and plays roles in cell differentiation via its role in androgen and estrogen metabolism as well as that of other important lipids and bioactive lipid derivatives. S1P lyase is expressed in the endoplasmic reticulum in many cells. Interestingly, because Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning, its catabolism by S1P lyase is very important in recovery from heart attacks or other ischemia related events, and thus S1P lyase is being examined as a potential new therapeutic target for reperfusion therapy in heart disease. |
| Immunogen【免疫原】 | Epitope: cytoplasmic domain Linear peptide corresponding to the cytoplasmic domain of Mouse S1P lyase. |
| Application【应用】 | Western Blotting Analysis: A representative lot of this antibody detected S1P lyase in 30 μg of lysate from various mice tissues (Bektas, M., et al. (2010). Journal of Biological Chemistry Vol. 285, NO. 14, pp. 10880–10889) Research Category Signaling Metabolism Research Sub Category Lipid Metabolism & Weight Regulation Lipid Signaling This Anti-S1P lyase Antibody is validated for use in Western Blotting for the detection of S1P lyase. |
| Quality【质量】 | Evaluated by Western Blotting in mouse lung tissue lysate. Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer with 0.05% sodium azide. Antigen Affinity Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_033189 |
| UniProt accession no.【UniProt登记号】 | Q8R0X7 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 56 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
