Anti-PQBP1 Antibody

32160702

NA.41

Polyglutamine-binding protein 1 (PQBP1), also known as PQBP-1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1, is encoded by the gene name PQBP1/ NPW38/ JM26. Recent studies have implied that PQBP1 may suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. PQBP1 has also been shown to activate transcription directly, or via association with the transcription machinery. PQBP1 might be involved in ATXN1 mutant-induced cell death. PQBP1 has been shown to interact with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. In addition, PQBP1 interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. PQBP1 forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. PQBP1 is widely expressed with high levels in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. Mutations in PQBP1 have been associated with Renpenning syndrome 1 (RENS1), an X-linked mental retardation syndrome characterized by mental retardation, microcephaly, short stature, and small testes.

Epitope: unknown
KLH-conjugated linear peptide corresponding to the unknown of Human PQBP1.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PQBP1 in human cardiac myocytes and pancreatic tissue.
Anti-PQBP1 is an antibody against PQBP1 for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Evaluated by Western Blotting in Human Hippocampus tissue lysate.

Western Blotting Analysis: A 0.5 µg/mL dilution of this antibody detected PQBP1 in 10 µg of Human Hippocampus tissue lysate.

Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Antigen Affinity Purified

Concentration: Please refer to lot specific datasheet.

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

human

primate (based on 100% sequence homology)

immunohistochemistry: suitable
western blot: suitable

NP_001027553

O60828

wet ice

human ... PQBP1(10084)

~38 kDa observed. Predicted to cross-react to Isoforms 1, 2, 3, and 6. Maybe detected upon longer exposure times.

Stable for 1 year at 2-8°C from date of receipt.

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12 - Non Combustible Liquids

WGK 1