Anti-Phospho-JNK1/2/3-T183/T183/T221 antibody produced in rabbit

rabbit

100

primary antibodies

monoclonal

liquid

rat, human, mouse

1.61 mg/mL

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

P45983/P45984/P53779

wet ice

−20℃

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

A phospho specific peptide corresponding to residues surrounding T183/T183/T221 of human JNK1/2/3

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.