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Anti-ORP150/GRP170/HSP12A antibody produced in rabbit

产品编号:4111725
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
41117254660
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody product type
primary antibodies
clone【克隆】
monoclonal
form【形式】
liquid
species reactivity
human, mouse, rat
concentration【浓度】
0.15 mg/mL
technique(s)
immunohistochemistry: 1:50-1:200
western blot: 1:5000-1:10000
UniProt accession no.【UniProt登记号】
Q9Y4L1
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... HYOU1(10525)
基本信息
General description【一般描述】
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Immunogen【免疫原】
A synthesized peptide derived from human ORP150/GRP170/HSP12A
Physical form【外形】
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
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