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Anti-Myelin Basic Protein Antibody, a.a. 82-87

产品编号:4110645
规格:culture supernatant, clone 12, Chemicon®
包装规格:1 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
41106451 ML5680
产品别名

Anti-Myelin Basic Protein Antibody, a.a. 82-87

MBP

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The two major components of CNS myelin are Myelin Basic Protein (MBP) and proteolipid protein (PLP), occuring in roughly equimolar proportions. There are many neurological disorders associated with deficiencies of myelin assembly and structure. For example Multiple Sclerosis is a human disease due to multiple factors but generally characterized by the degradation of the myelin sheath. MBP ususally refers to the 18.5 kDa isoform, which is one of the most abundant proteins of the myelin sheath of adult human and bovine CNS. Genetically, MBP is the product of differential splicing of a single mRNA transcript. In humans there are 4 isoforms, 21.5, 20.2, 18.5, and 17.2 kDa. Thus, MBP are present in multiple isoforms, part of a large family of developmentally expressed, translocatable, and highly post-translationally modifed proteins with multiple binding partners. Structurally, MBP displays a predominately unorganized form with greater than 75% in random coil. Other non-CNS related functions of myelin include insulin induction and glucagon release from pancreatic islets.
Specificity【特异性】
Reacts with MBP from all species tested including human, bovine, sheep, rabbit, mouse, rat, guinea pig and chicken.
Reacts with MBP from all species tested. It reacts weakly with peptides ending in the phe 91 where the 91-92 phe-phe bond is broken. Synthetic peptide 82-99 reacts very well as does intact MBP. Mapped to the region DENPVV.
Immunogen【免疫原】
Epitope: a.a. 82-87
Bovine myelin basic protein
Application【应用】
Research Sub Category
Neuronal & Glial Markers

Neurochemistry & Neurotrophins
Immunohistochemistry:
A previous lot of this antibody was used on frozen sections.

ELISA/RIA:
1:1000 dilution of a previous lot of this antibody was used in ELISA/RIA.

Western Blotting:
Identifies an 18-20kDa band in westerns.

Optimal working dilutions must be determined by end user.
Anti-Myelin Basic Protein Antibody, a.a. 82-87 is an antibody against Myelin Basic Protein for use in ELISA, IC, IH, RIA & WB.
Research Category
Neuroscience
Quality【质量】
Evaluated by Western Blot on Mouse brain lysates.

Western Blot Analysis:
1:500 dilution of antibody lot detected four isoforms of MBP on 10 µg of Mouse brain lysates.
Physical form【外形】
Unpurified
Liquid containing 0.1% sodium azide.
Analysis Note【分析说明】
Control
Brain tissue
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information【法律信息】
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
rat
antibody form【抗体形式】
culture supernatant
antibody product type
primary antibodies
clone【克隆】
12, monoclonal
species reactivity
sheep, all, mouse, rat, guinea pig, chicken, bovine, rabbit, human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
radioimmunoassay: suitable
western blot: suitable
isotype【同位素/亚型】
IgG2a
NCBI accession no.【NCBI登记号】
NM_001025094.1
UniProt accession no.【UniProt登记号】
P02686
shipped in【运输】
dry ice
产品说明
Target description【目标描述】
18-20 kDa
Storage and Stability【储存及稳定性】
Stable for 1 year at -20ºC from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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