Anti-Microsialin/CD68 Antibody, clone 9

32160702

NA.41

Microsialin/CD68, also known as Macrosialin, Gp110, CD_antigen 68, or CD68, and encoded by the gene CD68, is a membrane protein expressed in macrophages (and other cells) that appears to play a role in the phagocytic activities of tissue macrophages both in intracellular lysosomal metabolism but also in extracellular cell to cell interactions and cell pathogen interactions. Microsialin binds to tissue and organ-specific lectins or selectins mediating homing of macrophage subsets to particular sites. Also, rapid recirculation of Microsialin from the endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selection-bearing substrates or other cells. Microsialin is expressed in blood monocytes and tissue macrophages primarily but is also found expressed in lymphocytes, fibroblasts and endothelial cells so it is not an exclusive marker for macrophages. Also Microsialin is expressed on many tumor cells which seem to allow the tumor cells to attach to selectins on the vascular endothelium facilitating their dissemination to secondary sites.

Recombinant protein corresponding to mouse Microsialin/CD68.

Anti-Microsialin/CD68 Antibody, clone 9 is an antibody against Microsialin/CD68 for use in flow cytometry.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

Evaluated by Flow Cytometry in RAW264.7 cells.

Flow Cytometry Analysis: 2 µg of this antibody detected Microsialin/CD68 in 1X10E6 cells.

This antibody was produced in collaboration with the Scripps Research Institute. For Scripps Research Institute Validation (Click Here)

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Format: Purified

100

rat

purified immunoglobulin

primary antibodies

9, monoclonal

mouse

1 mg/mL

flow cytometry: suitable

IgG2aκ

NP_033983

P31996

wet ice

Stable for 1 year at 2-8°C from date of receipt.

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12 - Non Combustible Liquids

WGK 1