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Anti-KLRG1 Antibody (mouse), APC, clone 2F1
| 产品编号： | 4109577 |
| 规格： | clone 2F1, 0.2 mg/mL, from hamster(Syrian) |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-KLRG1 Antibody (mouse), APC, clone 2F1
Killer cell lectin-like receptor subfamily G member 1, Mast cell function-associated antigen 2F1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | This golden syrian hamster monoclonal antibody Anti-KLRG1 (mouse), APC, clone 2F1 validated for use in IP & Flow Cytometry for the detection of KLRG1. The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations. |
| Quality【质量】 | The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.06 μg of this antibody detected KLRG1 in one million C57Bl/6 splenocytes. |
产品性质
| biological source【生物来源】 | hamster (Syrian) |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | Allophycocyanin conjugate |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 2F1, monoclonal |
| species reactivity | mouse |
| concentration【浓度】 | 0.2 mg/mL |
| technique(s) | flow cytometry: suitable immunoprecipitation (IP): suitable |
| isotype【同位素/亚型】 | IgG |
| UniProt accession no.【UniProt登记号】 | O88713 |
| shipped in【运输】 | wet ice |
产品说明
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
