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Anti-FYVE Antibody, clone 7F11.1

产品编号:4107995
规格:clone 7F11.1, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4107995100 μG5850
产品别名

Anti-FYVE Antibody, clone 7F11.1

Zinc finger FYVE domain-containing protein 26, FYVE domain-containing centrosomal protein, FYVE-CENT, Spastizin, FYVE

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
FYVE, also known as Zinc finger FYVE domain-containing protein 26, or FYVE domain-containing centrosomal protein (FYVE-CENT), or Spastizin, and encoded by the gene ZFYVE26/KIAA0321, is a phosphosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis. FYVE is recruited to the midbody during cytokinesis and acts as a regulator of abscission. FYVE also be required for efficient homologous recombination DNA double-strand break repair. FYVE is cytoskeleton associated and localized in the cytoplasm in resting cells but at the centrosome during cell division. FYVE is expressed in all cells and tissues. Defects in FYVE may be associated with Spastic paraplegia 15, a form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
Immunogen【免疫原】
GST-tagged recombinant protein corresponding to human FYVE.
Application【应用】
Anti-FYVE Antibody, clone 7F11.1 detects level of FYVE & has been published & validated for use in FYVE.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human frontal cortex and thalamus tissues.
Quality【质量】
Evaluated by Immunohistochemistry in human cerebellum tissue.

Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human cerebellum tissue.
Physical form【外形】
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
7F11.1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin)
isotype【同位素/亚型】
IgG2aκ
NCBI accession no.【NCBI登记号】
NP_056161
UniProt accession no.【UniProt登记号】
Q68DK2
shipped in【运输】
wet ice
Gene Information
human ... ZFYVE26(23503)
产品说明
Target description【目标描述】
~285 kDa calculated. Four isoforms are known to exist at 285 kDa (isoform 1), 283 kDa (isoform 2), 78 kDa (isoform 3), and 89 kDa (isoform 4).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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