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Anti-FYVE Antibody, clone 7F11.1
产品别名
Anti-FYVE Antibody, clone 7F11.1
Zinc finger FYVE domain-containing protein 26, FYVE domain-containing centrosomal protein, FYVE-CENT, Spastizin, FYVE
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | FYVE, also known as Zinc finger FYVE domain-containing protein 26, or FYVE domain-containing centrosomal protein (FYVE-CENT), or Spastizin, and encoded by the gene ZFYVE26/KIAA0321, is a phosphosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis. FYVE is recruited to the midbody during cytokinesis and acts as a regulator of abscission. FYVE also be required for efficient homologous recombination DNA double-strand break repair. FYVE is cytoskeleton associated and localized in the cytoplasm in resting cells but at the centrosome during cell division. FYVE is expressed in all cells and tissues. Defects in FYVE may be associated with Spastic paraplegia 15, a form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. |
Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human FYVE. |
Application【应用】 | Anti-FYVE Antibody, clone 7F11.1 detects level of FYVE & has been published & validated for use in FYVE. Research Sub Category Apoptosis - Additional Research Category Apoptosis & Cancer Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human frontal cortex and thalamus tissues. |
Quality【质量】 | Evaluated by Immunohistochemistry in human cerebellum tissue. Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human cerebellum tissue. |
Physical form【外形】 | Format: Purified Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Protein G Purified |
Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | 7F11.1, monoclonal |
species reactivity | human |
technique(s) | immunohistochemistry: suitable (paraffin) |
isotype【同位素/亚型】 | IgG2aκ |
NCBI accession no.【NCBI登记号】 | NP_056161 |
UniProt accession no.【UniProt登记号】 | Q68DK2 |
shipped in【运输】 | wet ice |
Gene Information | human ... ZFYVE26(23503) |
产品说明
Target description【目标描述】 | ~285 kDa calculated. Four isoforms are known to exist at 285 kDa (isoform 1), 283 kDa (isoform 2), 78 kDa (isoform 3), and 89 kDa (isoform 4). |
Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |