Anti-Complement Factor H antibody produced in goat

100

goat

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

human

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

P08603

dry ice

−20℃

human ... CFH(3075)

Complement factor H (CFH) codes for 20 complement-control protein modules (CCPs 1–20). It is expressed in the liver, mesangial cells, endothelial cells and fibroblasts. It is a membrane cofactor protein. The CFH gene is localized on human chromosome 1q31.3.

Peptide with sequence C-HLVPDRKKDQYK from the internal region of the protein sequence according to NP_000177.2.

Complement factor H (CFH) is a negative regulator of the alternative pathway. It suppresses spontaneous complement activation and its response on self surfaces. CFH possesses decay-accelerating activity and destabilizes the C3b amplification in the alternate complement pathway. It also has a role in C3b cleavage by its cofactor activity. The protein has been linked to various diseases like age-related macular degeneration, kidney disorder and C3 glomerulopathy. CFH might prevent complement activation in ischemic renal injury by binding to tubular epithelial cells.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 2