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产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody product type | primary antibodies |
| clone【克隆】 | monoclonal |
| form【形式】 | liquid |
| species reactivity | human |
| concentration【浓度】 | 1.4 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no.【UniProt登记号】 | P60953 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CDC42(998) |
基本信息
| General description【一般描述】 | The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] |
| Immunogen【免疫原】 | A synthesized peptide derived from human CDC42 |
| Physical form【外形】 | Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
