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Anti-CD11b Antibody (human/mouse), APC-Cy7, clone M1/70
产品别名
Anti-CD11b Antibody (human/mouse), APC-Cy7, clone M1/70
Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD antigen CD11b
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b. |
| Immunogen【免疫原】 | Immunogen information for this antibody is proprietary information. |
| Application【应用】 | Research Category Inflammation & Immunology This Rat Monoclonal Antibody Anti-CD11b (human/mouse), APC-Cy7, clone M1/70, Cat. No. MABF362 is validated for use in IP, IHC, FC, IF for the detection of CD11b. |
| Physical form【外形】 | Size Exclusion Chromatography Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | APC-Cy7 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | M1/70, monoclonal |
| species reactivity | human, mouse |
| concentration【浓度】 | 0.2 mg/mL |
| technique(s) | flow cytometry: suitable immunofluorescence: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable |
| isotype【同位素/亚型】 | IgG2bκ |
| UniProt accession no.【UniProt登记号】 | P05555 P11215 |
| shipped in【运输】 | wet ice |
产品说明
| Storage and Stability【储存及稳定性】 | It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
