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Anti-CCN1/CYR61 Antibody
| 产品编号： | 4105694 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-CCN1/CYR61 Antibody
Protein CYR61, CCN family member 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | CCN1 (cysteine-rich 61 or CYR61), a ubiquitous angiogenic factor, is a member of the CNN family, which is also comprised of CTGF, WISP-1, WISP-2, and WISP-3. It is a multidomain protein, containing one each of CTCK, IGFBP, TSP type-1, and VWFC domains. CCN1 is associated with the extracellular matrix and functions as a ligand for integrin receptors. It is expressed in response to growth factor stimulation, and mediates various cellular processes, including cell adhesion, migration, proliferation, angiogenesis, extracellular-matrix remodeling, and placental development. Previous studies have indicated that it may also play a role in wound healing by influencing the expression of genes required for this process, such as TIMP1, PAI-1, VEGA-A, VEGA-C, MMP1, MMP3, and uPA. CCN1 has also been implicated in breast cancer. |
| Specificity【特异性】 | This antibody recognizes the CTCK domain of: CCN1/CYR61 |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the CTCK domain of human CCN1/CYR61. Epitope: CTCK domain |
| Application【应用】 | Immunohistochemistry Analysis: 1:200 dilution from a representative lot detected CCN1/CYR61 in human kidney tissue. Research Sub Category Apoptosis - Additional Detect CCN1/CYR61 using this Anti-CCN1/CYR61 Antibody validated for use in Western Blotting, IHC(P). Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blot in NIH/3T3 cell lysate. Western Blot Analysis: 2 µg/mL of this antibody detected CCN1/CYR61 in 10 µg of NIH/3T3 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control NIH/3T3 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human, rat |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001545 |
| UniProt accession no.【UniProt登记号】 | O00622 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... CYR61(3491) |
产品说明
| Target description【目标描述】 | ~53 kDa observed. The calculated molecular weight of this protein is 42 kDa, but can be observed at higher molecular weights due to glycosylation. A degradation fragment may be observed at ~15 kDa in some lysates. (Rother et al., 2010) |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
