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Anti-Caspase-5 Antibody
| 产品编号： | 4105611 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Caspase-5 Antibody
Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p202.Caspase-5 subunit p10
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Caspase-5 (CASP5) is a member of the peptidase C14A family that can be divided into the apoptotic and inflammatory caspase subfamilies. Members of this subfamily include caspase-1, -4, -5, and -12. When activated, these caspases result in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18. Caspase-5 is expressed in barely detectable amounts in most tissues except brain, with highest levels being found in lung, liver and skeletal muscle. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. |
| Specificity【特异性】 | This antibody recognizes the intermediate domain of Caspase-5. |
| Immunogen【免疫原】 | Epitope: Intermediate domain KLH-conjugated linear peptide corresponding to the intermediate domain of human Caspase-5. |
| Application【应用】 | Detect Caspase 5 using this rabbit polyclonal antibody, Anti-Caspase-5 Antibody validated for use in western blotting, ICC & Immunofluorescence. Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected Caspase-5 in P815 cells. Immunofluorescence Analysis: 2 µg/mL from a representative lot detected Caspase-5 in P815 cells. Research Category Signaling Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in Ramos cell lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected Caspase-5 in Ramos cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Ramos cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable immunofluorescence: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | P51878 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~48 kDa observed. Uncharacterized bands may appear in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
