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Anti-Caspase-10 Antibody
| 产品编号： | 4105609 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Caspase-10 Antibody
Casp-10, Caspase-10
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Caspase-10 is a member of the peptidase C14A family and is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is expressed in many tissues and cell lines with the lowest expression found in brain, kidney, prostate, testis, and colon. Mutations in Caspase-10 have been associated with autoimmune lymphoproliferative syndrome type 2A and gastric cancer. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of Caspase-10. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the C-terminus of human Caspase-10. Epitope: C-terminus |
| Application【应用】 | Research Sub Category Apoptosis - Additional Research Category Apoptosis & Cancer Detect Caspase 10 using this rabbit polyclonal antibody, Anti-Caspase-10 Antibody validated for use in western blotting. |
| Quality【质量】 | Evaluated by Western Blotting in HeLa, Jurkat, A431, and K562 whole cell lysates. Western Blotting Analysis: 1 µg/mL of this antibody detected Caspase-10 in 15 µg of HeLa, Jurkat, A431, and K562 whole cell lysates. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control HeLa, Jurkat, A431, and K562 whole cell lysates |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q92851 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~59 kDa observed. Uniprot describes 6 isoforms ranging from ~31 kDa to ~59 kDa Uncharacterized bands may appear in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
