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Anti-Betacellulin Antibody, clone 6G10.1

产品编号:4105368
规格:clone 6G10.1, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4105368100 μG5010
产品别名

Anti-Betacellulin Antibody, clone 6G10.1

Probetacellulin, Betacellulin, BTC

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein. Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal. Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4. Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease. Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment.
Specificity【特异性】
Clone 6G10.1 is expected to detect prepro-, pro-, and mature betacellulin.
Immunogen【免疫原】
Epitope: Mature betacellulin
GST-tagged human recombinant full-length mature betacellulin.
Application【应用】
This Anti-Betacellulin Antibody, clone 6G10.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of Betacellulin .
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Betacellulin in human pancreas tissue.
Quality【质量】
Evaluated by Western Blotting in human pancreas tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Betacellulin in 10 µg of human pancreas tissue lysate.
Physical form【外形】
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
6G10.1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_001720
UniProt accession no.【UniProt登记号】
P35070
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~20 kDa observed. Preprobetacellulin (19.7 kDa calculated); Probetacellulin (16.6 kDa calculated); Betacellulin (9.0 kDa calculated). Due to posttranslational glycosylation, target band(s) will migrate with a higher apparent M.W. than caluclated.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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