Anti-BCOR antibody, Mouse monoclonal

purified from hybridoma cell culture

BR-4

liquid

human

~1 mg/mL

immunoblotting: 2-4 μg/mL using human HeLa nuclear extract
immunofluorescence: 2-4 μg/mL using human HeLa cells

IgG1

Q6W2J9

dry ice

−20℃

BCOR encodes a ubiquitously expressed protein which is involved in BCL6-mediated transcriptional repression.1 Originally it was identified as a novel BCL6 corepressor via its interaction with the site-specific DNA-binding transcription factor BCL6, whose aberrant expression drives formation of diffuse large B-cell lymphomas.

Monoclonal Anti-BCOR antibody specifically recognizes human BCOR protein.

The antibody may be used in various immunochemical techniques including Immunoblotting (∼190 kDa) and Immunofluorescence.

NCOR and SMRT, was recently demonstrated to occupy the majority of its DNA binding sites independently from BCL6, reflecting its multiple interaction partners. BCOR also forms a Polycomb repressor complex 1 (PRC1)-like complex with PCGF1, KDM2B, RING1, SKP1, RYBP, and RNF2, and can bind to both class I and II histone deacetylases.1 BCOR is specifically and strongly expressed during embryonic development where it plays a critical role in transcriptional regulation, as BCOR mutations are associated with the X-linked inherited diseases Lenz microphthalmia and Oculofaciocardiodental syndrome (OFCD).

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 1