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Anti-ASIC1 Antibody, clone N271/44
产品别名
Anti-ASIC1 Antibody, clone N271/44
Acid-sensing ion channel 1, ASIC1, Acid-sensing ion channel, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Acid-sensing ion channels (ASICs) are broadly distributed in the nervous system where they contribute to certain sensory processes. In particular, they survey moderate decreases in extracellular pH as a means to regulate acid levels and acid-induced pain. ASICs thereby serve as a popular target for the treatment of acidosis. The acid-sensing ion channel 1 consists of a trimeric protein, where each subunit is composed of two transmembrane spanning helices, a highly organized ectodomain, and an intracellular N-terminus and C-terminus. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of ASIC1. |
| Immunogen【免疫原】 | Epitope: C-terminus Recombinant protein corresponding to the C-terminus of mouse ASIC1. |
| Application【应用】 | Western Blot: A representative lot detected ASIC1 in WT mice, but demonstrated a loss of signal in ASIC1 knockout mice. Immunohistochemistry Analysis: A representative lot detected ASIC1 in rat brain tissue (Prof. J. Trimmer, University of California, Davis). Anti-ASIC1 Antibody, clone N271/44 detects level of ASIC1 & has been published & validated for use in Western Blotting & IHC. Research Category Neuroscience Research Sub Category Developmental Neuroscience |
| Quality【质量】 | Evaluated by Western Blot in rat brain tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected ASIC1 in 10 µg of rat brain tissue lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Rat brain tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | N271/44, monoclonal |
| species reactivity | mouse, rat |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_033727 |
| UniProt accession no.【UniProt登记号】 | Q6NXK8 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~60 kDa observed. Two isoforms at ~60 kDa and ~62 kDa are known to exist. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
