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Anti-Corticotropin-Releasing Factor Receptor 2 Antibody
产品别名
Anti-Corticotropin-Releasing Factor Receptor 2 Antibody
Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-Releasing Factor Receptor 2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Corticotropin-Releasing Factor Receptor 2 (CRFR2) is a G-protein coupled receptor for CRH (Corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Ligand binding activates adenylate cyclase leading to an increase in cAMP levels and subsequent gene activation. CRFR2 binds Urocortin (UCN) with the highest affinity. CRFR2 is localized to the plasma membrane, and CRFR2 has numerous isoforms but their functional importance remains to be discovered. Latest research is focused upon antagonists of the receptors for CRF. Astressin2-B, which is specific for CRFR2 and Astressin B which binds both CRFR1 and CRFR2 are two recent peptide antagonists. The research hopes to develop treatments for many CRF-dependent diseases in the periphery such as irritable bowel syndrome and even perhaps various social behaviors such as anxiety and anti-social activities. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Corticotropin-Releasing Factor Receptor 2 near the N-terminal. Epitope: Near N-terminal |
| Application【应用】 | This Anti-Corticotropin-Releasing Factor Receptor 2 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Corticotropin-Releasing Factor Receptor 2. Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human brain tissue lysate. Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Corticotropin-Releasing Factor Receptor 2 in human colon and Bowman′s capsule epithelial cells. Research Category Neuroscience Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in human colon tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Corticotropin-Releasing Factor Receptor 2 in 10 µg of human colon tissue lysate. |
| Linkage【联系】 | Replaces: AB9420 |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), hamster (based on 100% sequence homology), primate (based on 100% sequence homology), rat (based on 100% sequence homology), monkey (based on 100% sequence homology) |
| concentration【浓度】 | 1.0 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001189404 |
| UniProt accession no.【UniProt登记号】 | Q13324 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~49 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing from ~45-65 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
