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TopFluor® PI(3,4,5)P3
| 产品编号： | 4095922 |
| 规格： | 1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt), powder |
| CAS NO： | 2260795-37-5 |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品别名
2260795-37-5
TopFluor® PI(3,4,5)P3
基本信息
| Empirical Formula【经验(实验)分子式】 | C56H108 BF2 N7O23P4 |
| Molecular weight | 1420.19 |
| NACRES | NA.25 |
| General description【一般描述】 | Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane. PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor® PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain. |
| Biochem/physiol Actions【生化/生理作用】 | Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt. PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor® PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores. |
| Legal Information【法律信息】 | TopFluor is a registered trademark of Avanti Polar Lipids, Inc. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 810189P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
