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16:0 Cardiolipin
| 产品编号： | 4095596 |
| 规格： | 1′,3′-bis[1,2-dipalmitoyl-sn-glycero-3-phospho]-glycerol (sodium salt), powder |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
基本信息
| Empirical Formula【经验(实验)分子式】 | C73H140Na2O17P2 |
| Molecular weight | 1397.81 |
| NACRES | NA.25 |
| General description【一般描述】 | Cardiolipins are anionic teraacylphospholipid, present in inner mitochondrial membrane eukaryotic cells and bacterial cytoplasmic membranes. 16:0 cardiolipin is synthesized by de novo pathway. 16:0 Cardiolipin binds to myeloid differentiation protein 2 (MD2). Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup. The 16:0 number indicates the fatty acyl substituents attached to the carbons of glycerol. |
| Application【应用】 | 16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity. |
| Biochem/physiol Actions【生化/生理作用】 | Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions. Cardiolipin regulates the dynamic organization of membranes and cell division. It is involved in proton uptake pathway. Cardiolipin plays an important role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It modulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis. Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy. The association of cardiolipin and cytochrome c determines the action of proteins involved in oxidative phosphorylation and apoptosis. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 710333P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (710333P-25mg) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Flash Point(F)【闪点(F)】 | 755.6 - 820.4 °F |
| Flash Point(C)【闪点(C)】 | 402 - 438 ℃ |
