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TPEN-CAS 16858-02-9-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4095193 | 100 MG | 2470 |
产品别名
16858-02-9
TPEN-CAS 16858-02-9-Calbiochem
N,N,N',N'- tetrakis-(2-Pyridylmethyl)ethylenediamine
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H28N6 |
| Molecular weight | 424.54 |
| MDL number | MFCD00036918 |
| General description【一般描述】 | Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826). Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca2+ in cells. Has an extremely high affinity for heavy metals but a low affinity for Ca2+ and Mg2+. Induces DNA fragmentation when chelated with Zn2+ and causes apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2. Shown to be useful in extracting Aβ depostis from Alzheimer′s disease brain tissue. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209. Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223. Aballay, A., et al. 1995. Biochem. J.312, 919. Jiang, S., et al. 1995. Lab. Invest.73, 111. Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon33, 539. McCabe, M.J., et al. 1993. Lab. Invest. 69, 101. Hinkle, P.M., et al. 1992. J. Biol. Chem.267, 25553. Baba, A., et al. 1991. Brain Res. 557, 103. Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224. Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol.138, 593. Raspe, E., et al. 1989. Eur. J. Pharmacol.163, 345. Arslan, L.P., et al. 1985. J. Biol. Chem.260, 2719. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (titration) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | tan |
| solubility【溶解性】 | ethanol: 10 mg/mL 0.1 M phosphate pH 7.0: 25 μM DMSO: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 15-25℃ |
| InChI | 1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2 |
| InChI key | CVRXLMUYFMERMJ-UHFFFAOYSA-N |
| packaging【包装】 | 100 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
