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Licochalcone-A, Synthetic-CAS 58749-22-7-Calbiochem
| 产品编号： | 4095174 |
| 规格： | An estrogenic flavonoid with anti-tumor and antiparasitic properties. |
| CAS NO： | 58749-22-7 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4095174 | 10 MG | 1230 | |||
| 4095174 | 50 MG | 3990 |
产品别名
58749-22-7
Licochalcone-A, Synthetic-CAS 58749-22-7-Calbiochem
(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H22O4 |
| Molecular weight | 338.40 |
| MDL number | MFCD01417903 |
| General description【一般描述】 | An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism. An estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Anti-tumor and antiparasitic properties Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Harmful (C) |
| Preparation Note【制备说明】 | Further dilute 1:10 with aqueous buffer or medium just prior to use. |
| Reconstitution【重悬】 | Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653. Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793. Haraguchi, H., et al. 1998. Phytochemistry 48, 125. Park, E.J., et al. 1998. Planta Med. 64, 464. Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470. Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥96% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: 10 mg/mL ethanol: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+ |
| InChI key | KAZSKMJFUPEHHW-DHZHZOJOSA-N |
| packaging【包装】 | 10, 50 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 + H312 + H332 |
| Precautionary Statements | P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
