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5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole-CAS 53-85-0-Calbiochem
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4095160 | 50 MG | 2380 |
产品别名
53-85-0
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole-CAS 53-85-0-Calbiochem
5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H12Cl2N2O4 |
| Molecular weight | 319.14 |
| MDL number | MFCD00036785 |
| General description【一般描述】 | Accentuates premature termination of transcription close to the promoter. Useful for isolation of RNA sequences near promoter sites that are responsible for mRNA formation. Useful for reversible superinduction of human fibroblast cultures. Potent, ATP-competivie and specific inhibitor of casein kinase II (IC50 = 6 µM). Has been used to inhibit RNA polymerase II transcription, which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target casein kinase II Reversible: no Product competes with ATP. Cell permeable: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Preparation Note【制备说明】 | May require warming (47°C) to achieve complete dissolution. |
| Reconstitution【重悬】 | Room temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681. Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev.37, 284. Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806. Zandomeni, R., et al. 1986. J. Biol. Chem.261, 3414. Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461. Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561. Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA79, 3167. Stewart, M.W., et al. 1977. J. Gen. Virol.37, 221. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (TLC) |
| form【形式】 | solid |
| potency【效能】 | 6 μM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 3 mg/mL ethanol: 3 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1 |
| InChI key | XHSQDZXAVJRBMX-DDHJBXDOSA-N |
| packaging【包装】 | 50 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
