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白细胞介素4 人
Interleukin-4 human
| 产品编号： | 4093801 |
| 规格： | IL-4, potency:, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
白细胞介素4 人
Interleukin-4 human
基本信息
| MDL number | MFCD00151705 |
| NACRES | NA.77 |
| Quality【质量】 | endotoxin tested |
| General description【一般描述】 | Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells. |
| Biochem/physiol Actions【生化/生理作用】 | Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution of 1x PBS. |
| Preparation Note【制备说明】 | HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications. |
| Analysis Note【分析说明】 | The specific activity was determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line). |
| Legal Information【法律信息】 | HumanKine is a registered trademark of Proteintech Group, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | >95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≤0.6 ng/mL EC50 |
| mol wt【分子量】 | dimer 14-19 kDa (glycosylated) |
| manufacturer/tradename | HumanZyme |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | <1 EU/μg |
| UniProt accession no.【UniProt登记号】 | P05112 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL4(3565) |
| packaging【包装】 | 10 μg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
