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Indomethacin-CAS 53-86-1-Calbiochem

产品编号:4093783
规格:A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.
CAS NO:53-86-1
包装规格:10 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
409378310 G2150
产品别名

53-86-1

Indomethacin-CAS 53-86-1-Calbiochem

1-( p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

基本信息
Empirical Formula【经验(实验)分子式】
C19H16ClNO4
Molecular weight
357.79
MDL number
MFCD00057095
General description【一般描述】
A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Reported to reduce Aβ42 levels independently of COX activity.
Biochem/physiol Actions【生化/生理作用】
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Warning【警告】
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
Other Notes【其他说明】
Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun.281, 483.
Weggen, S., et al. 2001. Nature414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins19, 271.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (by assay)
form【形式】
powder
potency【效能】
740 nM IC50
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
color【颜色】
white to off-white
solubility【溶解性】
ethanol: 20 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
10-30℃
InChI
1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
InChI key
CGIGDMFJXJATDK-UHFFFAOYSA-N
packaging【包装】
10 g in Alu drum
安全信息
Pictograms【象形图】
GHS06
Signal word【警示用语:】
Danger
Hazard Statements
H300
Precautionary Statements
P264 - P270 - P301 + P310 - P405 - P501
Hazard Classifications【危险分类】
Acute Tox. 1 Oral
Storage Class Code【储存分类代码】
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
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